Del Picchia was educated in the law, and was a practicing attorney in Itapira when he began writing poetry. He moved to São Paulo, the city of his birth, and became acquainted with Mário de Andrade and the other young modernists in the city. He was a member of the Group of Five, along with Andrade, poet Oswald de Andrade, and painters Tarsila do Amaral and Anita Malfatti, and was one of the key participants of the Week of Modern Art in São Paulo, in February 1922, a watershed event in the history of modernism of arts in Brazil.
Because del Picchia outlived his literary generation, he received in person much more honor for his role in the creation of Modernismo than any of his youthful colleagues. By the time of his death he had received most of the highest governmental, academic, and private honors in Brazil, and his house in Itapira is now a museum.